Erythrocyte as a link between basic and clinical research

© 2011 – IOS Press and the authorsWe review the major hemorheological experimental studies that show the erythrocyte aggregation as a link between basic and clinical research. The results of the clinical cross-sectional and longitudinal studies presented here will highlight the possible association between erythrocyte aggregation and plasma fibrinogen. Basic studies conducted in vitro are also mentioned as for its relevance in answering questions raised in clinical settings, as well as and in understanding the underlying influent factors in the erythrocyte tendency to aggregate and disaggregate.This work was supported by “Fundação para a Ciência e Tecnologia

Evidence that the degree of band 3 phosphorylation modulates human erythrocytes nitric oxide efflux – in vitro model of hyperfibrinogenemia

© 2011 – IOS Press and the authors. All rights reservedRecent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO) modulation. In the present pioneer in-vitro study, whole blood samples were harvested from healthy subjects and aliquots were incubated in the absence (control aliquots) and presence of fibrinogen at different degrees of band 3 phosphorylation, and the levels of NO, nitrite, nitrate and S-nitroglutathione (GSNO) were determined. Hyperfibrinogenemia interferes with erythrocyte NO mobilization without changing its efflux in a way that seems to be dependent of the degree of band 3 phosphorylation. In presence of higher fibrinogen concentrations the NO efflux is reinforced when band 3 is phosphorylated (p < 0.001). Higher levels of nitrite, nitrate and GSNO were documented (p < 0.05). However, the mechanisms by which fibrinogen signalling modulates erythrocyte function remain to be clarified and are currently under study. These conditions may be considered an approach to be followed in blood storage for transfusions.This study was supported by grants from the FCT - Fundação para a Ciência e a Tecnologia (project reference PTDC/SAU-OSM/73449/2006

On the propagation of semiclassical Wigner functions

We establish the difference between the propagation of semiclassical Wigner functions and classical Liouville propagation. First we re-discuss the semiclassical limit for the propagator of Wigner functions, which on its own leads to their classical propagation. Then, via stationary phase evaluation of the full integral evolution equation, using the semiclassical expressions of Wigner functions, we provide the correct geometrical prescription for their semiclassical propagation. This is determined by the classical trajectories of the tips of the chords defined by the initial semiclassical Wigner function and centered on their arguments, in contrast to the Liouville propagation which is determined by the classical trajectories of the arguments themselves.Comment: 9 pages, 1 figure. To appear in J. Phys. A. This version matches the one set to print and differs from the previous one (07 Nov 2001) by the addition of two references, a few extra words of explanation and an augmented figure captio

Quantization of multidimensional cat maps

In this work we study cat maps with many degrees of freedom. Classical cat maps are classified using the Cayley parametrization of symplectic matrices and the closely associated center and chord generating functions. Particular attention is dedicated to loxodromic behavior, which is a new feature of two-dimensional maps. The maps are then quantized using a recently developed Weyl representation on the torus and the general condition on the Floquet angles is derived for a particular map to be quantizable. The semiclassical approximation is exact, regardless of the dimensionality or of the nature of the fixed points.Comment: 33 pages, latex, 6 figures, Submitted to Nonlinearit

Manejo integrado de pragas do algodoeiro, com enfase aos efeitos colaterais dos pesticidas e o uso de controle biologico.

Conceitos gerais; Efeitos colaterais dos pesticidas no agroecossistema algodoeiro; Seletividade de inseticidas; Resistencia de plantas a insetos e suas interacoes como controle quimico e o controle biologico; Controle biologico na agroecosistema algodoeiro; Efeito das estrategias de controle no manejo integrado de pragas.bitstream/item/33367/1/MANEJO-INTEGRADO-DE-PRAGAS-DO-ALGODOEIRO.pd

Spin-glass behaviour on random lattices

The ground-state phase diagram of an Ising spin-glass model on a random graph with an arbitrary fraction $w$ of ferromagnetic interactions is analysed in the presence of an external field. Using the replica method, and performing an analysis of stability of the replica-symmetric solution, it is shown that $w=1/2$, correponding to an unbiased spin glass, is a singular point in the phase diagram, separating a region with a spin-glass phase ($w<1/2$) from a region with spin-glass, ferromagnetic, mixed, and paramagnetic phases ($w>1/2$)